Chemistry letters

A mild, efficient, and inexpensive protocol for the selective deprotection of TBDMS ethers using KHSO4

P Arumugam, G Karthikeyan, PT Perumal

文献索引：Arumugam, Pandurangan; Karthikeyan, Ganesan; Perumal, Paramasivan T. Chemistry Letters, 2004 , vol. 33, # 9 p. 1146 - 1147

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被引用次数: 19

摘要

Hydroxyl groups are widely present in many bioactive or- ganic molecules, sugars, nucleosides etc., hence protection and later deprotection is necessary for multistep transformation, es- pecially in the total synthesis of complex organic molecules. A variety of protective groups have been developed to mask the re- activity of hydroxyl group,1 however tert-butyldimethylsilyl protection is very common, because of its easy incorporation and stability to withstand different ...