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Semisynthetic cephalosporines. Synthesis of some substituted tetrazolyl acetic and propionic acids

Ľ Janda, Z Votický, J Jakubcová, J Světlík…

文献索引：Janda; Voticky; Jakubcova; et al. Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 7 p. 1699 - 1712

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被引用次数: 1

摘要

Abstract The N-alkylation of 5-[5-(substituted phenyl)-2-furyl]-1H-tetrazoles with ethyl bromoacetate or ethyl 3-bromopropionate afforded a mixture of 5-substituted ethyl 1-and 2- tetrazoyl acetates or propionates, which were separated and hydrolyzed to the corresponding 1-and 2-acetic or propionic acids, and used as intermediates for the synthesis of semisynthetic cephalosporine antibiotics. The prepared tetrazolyl acetic acids ...

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93674-59-0

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~94%

2-[5-[5-(3-chlorophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93789-15-2

2-[5-[5-(3-chlo...

5-[5-(3-chlorophenyl)furan-2-yl]-2H-tetrazole结构式

74637-99-3

5-[5-(3-chlorop...

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2-[5-[5-(3-chlorophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93789-15-2

2-[5-[5-(3-chlo...

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93674-65-8

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~92%

2-[5-[5-(3-methylphenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-56-0

2-[5-[5-(3-meth...

5-(5-(3-methylphenyl)-2-furyl)-1H-1-tetrazole结构式

93770-49-1

5-(5-(3-methylp...

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2-[5-[5-(3-methylphenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-56-0

2-[5-[5-(3-meth...

ethyl 2-(5-(5-(m-tolyl)furan-2-yl)-2H-tetrazol-2-yl)acetate结构式

93674-66-9

ethyl 2-(5-(5-(...

~89%

2-[5-[5-(3-methylphenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

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2-[5-[5-(3-meth...

5-(5-(3-methylphenyl)-2-furyl)-1H-1-tetrazole结构式

93770-49-1

5-(5-(3-methylp...

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2-[5-[5-(3-methylphenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93770-36-6

2-[5-[5-(3-meth...

ethyl 2-(5-(5-(4-bromophenyl)furan-2-yl)-1H-tetrazol-1-yl)acetate结构式

92973-08-5

ethyl 2-(5-(5-(...

~95%

2-[5-[5-(4-bromophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-55-9

2-[5-[5-(4-brom...

5-[5-(4-bromophenyl)furan-2-yl]-2H-tetrazole结构式

60838-08-6

5-[5-(4-bromoph...

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2-[5-[5-(4-bromophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-55-9

2-[5-[5-(4-brom...

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92973-11-0

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~92%

2-[5-(5-phenylfuran-2-yl)tetrazol-1-yl]acetic acid结构式

93770-60-6

2-[5-(5-phenylf...

5-(5-phenyl-furan-2-yl)-1(2)H-tetrazole结构式

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5-(5-phenyl-fur...

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2-[5-(5-phenylfuran-2-yl)tetrazol-1-yl]acetic acid结构式

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2-[5-(5-phenylf...

1,2-dimethyl-4,4-diethylpyrazolidine-3,5-dione结构式

76834-66-7

1,2-dimethyl-4,...

~91%

2-[5-[5-(4-bromophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93789-17-4

2-[5-[5-(4-brom...

5-[5-(4-bromophenyl)furan-2-yl]-2H-tetrazole结构式

60838-08-6

5-[5-(4-bromoph...

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2-[5-[5-(4-bromophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93789-17-4

2-[5-[5-(4-brom...

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92973-05-2

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~94%

2-[5-[5-(4-chlorophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-52-6

2-[5-[5-(4-chlo...

5-[5-(4-chloro-phenyl)-furan-2-yl]-1(2)H-tetrazole结构式

60838-07-5

5-[5-(4-chloro-...

~%

2-[5-[5-(4-chlorophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-52-6

2-[5-[5-(4-chlo...

未登录结构式

92973-07-4

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~95%

2-[5-[5-(2-chlorophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-54-8

2-[5-[5-(2-chlo...

5-[5-(2-chlorophenyl)furan-2-yl]-2H-tetrazole结构式

74638-00-9

5-[5-(2-chlorop...

~%

2-[5-[5-(2-chlorophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-54-8

2-[5-[5-(2-chlo...

未登录结构式

93674-60-3

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~92%

2-[5-[5-(2-chlorophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93789-16-3

2-[5-[5-(2-chlo...

5-[5-(2-chlorophenyl)furan-2-yl]-2H-tetrazole结构式

74638-00-9

5-[5-(2-chlorop...

~%

2-[5-[5-(2-chlorophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93789-16-3

2-[5-[5-(2-chlo...

ethyl 2-(5-(5-(2-methoxyphenyl)furan-2-yl)-1H-tetrazol-1-yl)acetate结构式

93674-62-5

ethyl 2-(5-(5-(...

~94%

2-[5-[5-(2-methoxyphenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-58-2

2-[5-[5-(2-meth...

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93770-50-4

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~%

2-[5-[5-(2-methoxyphenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-58-2

2-[5-[5-(2-meth...

ethyl 5-(5-(2-methoxyphenyl)-2-furyl)-2-tetrazolyl acetate结构式

93674-63-6

ethyl 5-(5-(2-m...

~90%

2-[5-[5-(2-methoxyphenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93770-38-8

2-[5-[5-(2-meth...

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93770-50-4

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~%

2-[5-[5-(2-methoxyphenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93770-38-8

2-[5-[5-(2-meth...

ethyl 2-(5-(5-(4-methoxyphenyl)furan-2-yl)-1H-tetrazol-1-yl)acetate结构式

92972-78-6

ethyl 2-(5-(5-(...

~95%

2-[5-[5-(4-methoxyphenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-57-1

2-[5-[5-(4-meth...

5-[5-(4-methoxyphenyl)furan-2-yl]-2H-tetrazole结构式

60838-11-1

5-[5-(4-methoxy...

~%

2-[5-[5-(4-methoxyphenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-57-1

2-[5-[5-(4-meth...

ethyl 2-(5-(5-(4-methoxyphenyl)furan-2-yl)-2H-tetrazol-2-yl)acetate结构式

93674-61-4

ethyl 2-(5-(5-(...

~90%

2-[5-[5-(4-methoxyphenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93770-37-7

2-[5-[5-(4-meth...

5-[5-(4-methoxyphenyl)furan-2-yl]-2H-tetrazole结构式

60838-11-1

5-[5-(4-methoxy...

~%

2-[5-[5-(4-methoxyphenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93770-37-7

2-[5-[5-(4-meth...

未登录结构式

93674-58-9

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~92%

2-[5-[5-(4-chlorophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93789-14-1

2-[5-[5-(4-chlo...

5-[5-(4-chloro-phenyl)-furan-2-yl]-1(2)H-tetrazole结构式

60838-07-5

5-[5-(4-chloro-...

~%

2-[5-[5-(4-chlorophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93789-14-1

2-[5-[5-(4-chlo...

未登录结构式

93746-43-1

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~89%

2-[5-[5-(2-nitrophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-59-3

2-[5-[5-(2-nitr...

5-[5-(2-nitrophenyl)furan-2-yl]-2H-tetrazole结构式

60838-05-3

5-[5-(2-nitroph...

~%

2-[5-[5-(2-nitrophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-59-3

2-[5-[5-(2-nitr...

未登录结构式

93674-64-7

未登录

~84%

2-[5-[5-(2-nitrophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93770-39-9

2-[5-[5-(2-nitr...

5-[5-(2-nitrophenyl)furan-2-yl]-2H-tetrazole结构式

60838-05-3

5-[5-(2-nitroph...

~%

2-[5-[5-(2-nitrophenyl)furan-2-yl]tetrazol-2-yl]acetic acid结构式

93770-39-9

2-[5-[5-(2-nitr...

未登录结构式

92973-06-3

未登录

~91%

2-[5-[5-(3-chlorophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-53-7

2-[5-[5-(3-chlo...

5-[5-(3-chlorophenyl)furan-2-yl]-2H-tetrazole结构式

74637-99-3

5-[5-(3-chlorop...

~%

2-[5-[5-(3-chlorophenyl)furan-2-yl]tetrazol-1-yl]acetic acid结构式

93770-53-7

2-[5-[5-(3-chlo...


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