A highly efficient total synthesis of (+)-himbacine

S Chackalamannil, RJ Davies, T Asberom…

文献索引：Chackalamannil, Samuel; Davies, Robert J.; Asberom, Theodros; Doller, Dario; Leone, Daria Journal of the American Chemical Society, 1996 , vol. 118, # 40 p. 9812 - 9813

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被引用次数: 79

摘要

Himbacine (1), a tetracyclic piperidine alkaloid isolated from the bark of the Australian pine tree of Galbulimima species, 1, 2 has attracted considerable attention due to its interesting structural features and promising biological property as a muscarinic receptor antagonist. 3 Positive modulation of synaptic acetylcholine levels by selective inhibition of presynaptic muscarinic receptors is a promising therapeutic approach for the treatment of senile ...