Synthesis, antibacterial evaluation and QSAR studies of 7-[4-(5-aryl-1, 3, 4-oxadiazole-2-yl) piperazinyl] quinolone derivatives

R Kumar, A Kumar, S Jain, D Kaushik

文献索引：Kumar, Rajnish; Kumar, Ashwani; Jain, Sandip; Kaushik, Darpan European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3543 - 3550

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被引用次数: 40

摘要

A series of 7-[4-(5-aryl-1, 3, 4-oxadiazole-2-yl) piperazinyl] quinolones (I-XXI) were synthesized using an appropriate synthetic route and characterized by elemental and spectral analysis. The antibacterial activities of all the synthesized compounds were evaluated against identifiable bacterial strains. Compounds III, IV, VII, VIII, IX, X, XI, XV, &XVIII showed better activity than parent compound against all the selected strains. QSAR ...