An improved synthesis of memantine hydrochloride: anti-Alzheimer's drug

…, M Ravikumar, V Himabindu, GM Reddy

文献索引：Reddy, Jambula Mukunda; Prasad, Ganji; Raju, Veeramalla; Ravikumar, Mylavarapu; Himabindu, Vurumidi; Reddy, Ghanta Mahesh Organic Process Research and Development, 2007 , vol. 11, # 2 p. 268 - 269

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被引用次数: 4

摘要

An economical new process route has been developed for the large-scale synthesis of memantine hydrochloride (1) an anti-Alzheimer's drug. The procedure involves the conversion of 1, 3-dimethyl adamantane (2) to formamide intermediate 8 as a key step, followed by hydrolysis to (1-amino-3, 5-dimethyl adamantane) hydrochloride (1) in good yield.