Benzisoxazole-and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents

…, KL Burgher, PG Conway, HB Hartman…

文献索引：Hrib, Nicholas J.; Jurcak, John G.; Burgher, Kendra L.; Conway, Paul G.; Hartman, Harold B.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2308 - 2314

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被引用次数: 30

摘要

A series of benzisoxazole-and benzisothiazole-3-carboxamides has been prepared and tested for potential antipsychotic activity. In general, the compounds showed an affinity for dopamine D2 and serotonin 5HTu and 5HTu receptors. Several members of this series have demonstrated activity in animal models predictive of potential antipsychotic activity. In addition, compounds 18, 19, 22, 27, 28, 43, and 44 have also shown a potential for ...