Fluorinated tricyclic neuroleptics with prolonged action: 8-Methoxy, 8-ethoxy, 8-ethylthio and 8-hydroxy derivatives of 3-fluoro-10-(4-methylpiperazino)-10, 11- …

…, J Pomykáček, J Metyšová, M Protiva

文献索引：Jilek; Pomykacek; Metysova; Protiva Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 5 p. 1382 - 1391

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被引用次数: 1

摘要

Abstract Acids IIa-c were prepared by reactions of (4-fluoro-2-iodophenyl) acetic acid with 4- methoxythiophenol, 4-ethoxythiophenol and 4-(ethylthio) thiophenol and cyclized with polyphosphoric acid in boiling toluene to dibenzo [b, f] thiepin-10 (11H)-ones IIIa-c. Reduction with sodium borohydride afforded the alcohols IVa-c which were treated with hydrogen chloride and gave the chloro derivatives Va-c. Substitution reactions with 1- ...