OH strategy is based on a stereospecific total synthesis of the" northern" C,]-CZ8 segment utilizing chirons derived from (S)-malic acid and L-isoleucine followed by coupling with a suitably functionalized" southern" segment, macrolactonization, stereocontrolled glycosylation, and adjustment of functionality. The allylic alcohol 2,[a] D 35.2', easily obtained from 1 via~-isoleucine,'was transformed into the six-carbon chiron 3,[(Y] D-67.3', ...
