The reductive alkylation of amines procedure was applied for the synthesis of aripiprazole 1a, buspirone 1b, and NAN-190 1c. ... Aripiprazole (7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl ]butoxy}-3,4-dihydro-1H-quinolin-2-one 1a and buspirone (8-{4-[4-(2-pyrimidinyl)-1-piperazinyl ]butyl}-8-azaspiro[4.5]decane-7,9-dione hydrochloride 1b are approved psychotropic drugs; NAN-190 (2-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}isoindoline-1,3-dione ...
