Bulletin of the Chemical Society of Japan

Synthesis and reactivity of N-trifluoromethyl-N-nitrosotrifluoromethanesulfonamide as a new type of trifluoromethylating agent.

T Umemoto, A Ando

文献索引：Umemoto, Teruo; Ando, Akira Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 2 p. 447 - 452

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被引用次数: 67

摘要

N-Trifluoromethyl-N-nitrosotrifluoromethanesulfonamide (TNS-Tf) was synthesized in a 58% yield by the reaction of trifluoronitrosomethane with hydroxylamine followed by the treatment with trifluoromethanesulfonyl fluoride in the presence of a base. TNS-Tf was demonstrated to be an effective trifluoromethylating agent photochemically or thermally for aromatics, thiols, disulfides, and uridine derivatives. The insertion reaction by two trifluoromethyl groups of ...