Regioselective reaction: synthesis of novel Mannich bases derived from 3-(4, 6-disubstituted-2-thiomethylpyrimidyl)-4-amino-5-mercapto-1, 2-4-triazoles and their …

B Lingappa, KS Girisha, B Kalluraya, NS Rai…

文献索引：Lingappa; Girisha; Kalluraya, Balakrishna; Satheesh Rai; Kumari, Nalilu Suchetha Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008 , vol. 47, # 12 p. 1858 - 1864

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被引用次数: 5

摘要

Abstract: A new series of 3-(4, 6-disubstituted-2-thiomethylpyrimidyl)-4-amino-5-mercapto-1, 2-4-triazoles have been synthesized. These triazoles on reaction with aldehydes in the presence of acid catalyst forms Schiff's bases. These Schiff's bases can exist both in the thiol as well as in the thione tautomeric form. However when these compounds are subjected to Mannich reaction, N-Mannich bases 7a-f are obtained rather than the S-Mannich bases. ...