Tetrahedron letters

The synthesis of new heterocyclic bridged ring systems. Analogs of tetrahydro-β-carbolines

C Gremmen, BEA Burm, MJ Wanner, GJ Koomen

文献索引：Gremmen, Christiaan; Burm, Brigitte E.A.; Wanner, Martin J.; Koomen, Gerrit-Jan Tetrahedron Letters, 1998 , vol. 39, # 11 p. 1441 - 1444

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被引用次数: 10

摘要

New bridged β-carbolines were synthesized via a short synthetic route. The key step of the sequence is a Pictet-Spengler condensation under neutral conditions, employing a cyclic amine and several aldehydes. Using 5, 5-diethoxypentanal gave a bridged analog which could be further ring closed to a new pentacyclic system.