Synthesis and antiallergic activity of 2-hydroxy-3-nitro-1, 4-naphthoquinones

DR Buckle, BCC Cantello, H Smith…

文献索引：Buckle; Cantello; Smith; Spicer Journal of Medicinal Chemistry, 1977 , vol. 20, # 8 p. 1059 - 1064

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被引用次数: 32

摘要

A selection of novel 2-hydroxy-3-nitro-l, 4-naphthoquinones are shown to be potent inhibitors of rat passive cutaneous anaphylaxis (PCA) and to have highest potency with alkyl substitution at both C-6 and C-7. The most potent compounds were 7c and 7e which produced a 50% inhibition in the rat PCA test at doses of about 10 wM/kg following subcutaneous administration and showed activity after oral administration. Related 4- ...