The search for TCP analogues binding to the low affinity PCP receptor sites in the rat cerebellum

J Hamon, F Espaze, J Vignon, JM Kamenka

文献索引：Hamon, Jacques; Espaze, Florence; Vignon, Jacques; Kamenka, Jean-Marc European Journal of Medicinal Chemistry, 1999 , vol. 34, # 2 p. 125 - 135

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被引用次数: 9

摘要

With the aim of obtaining selective ligands of the low affinity binding sites of [3H]-1-[1-(2- thienyl) cyclohexyl] piperidine ([3H] TCP) in the rat cerebellum, oxygen and sulfur atoms were introduced in the TCP structure and derivatives to obtain analogues with a lowered lipophilicity. These compounds, and others already obtained, were assayed comparatively to determine their affinities for three sites labeled with [3H] TCP: one in the forebrain, the ...