New Imidazole-Based Tripodal Ligands as CuB Site Mimics of Cytochrome c Oxidase

JP Collman, M Zhong, S Costanzo…

文献索引：Collman, James P.; Zhong, Min; Costanzo, Simona; Zhang, Chi Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8252 - 8256

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被引用次数: 16

摘要

Cytochrome c oxidase (CcO) is the terminal enzyme of the respiratory chains of mitochondria and aerobic bacteria. 1 Recent high-resolution X-ray diffraction analyses2 have disclosed that the active site of CcO is composed of a five-coordinate myoglobin-type iron center (heme a3) with an imidazole ligand from a histidine residue on the proximal side of the heme and a copper atom (CuB) coordinated to three histidine imidazoles on the ...