In vivo and in vitro effects of methacrylanilides and acetylcarboxanilide on alkaline phosphatase activity of Echinococcus multilocularis metacestodes

P Audin, ME Sarciron, J Paris, AF Petavy

文献索引：Audin, P; Sarciron, ME; Paris, J; Petavy, AF European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 285 - 289

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被引用次数: 5

摘要

Abstract In our search for effective chemotherapy of alveolar hydatid disease we are investigating key enzymes of Echinococcus multilocularis metacestodes. Isatin (2, 3- indolinedione) is well known as an inhibitor of alkaline phosphatase activity, and has been previously investigated. Acetylcarboxanilide, an 'open drug'of isatin and 2 methacrylanilides were evaluated for their ability to inhibit alkaline phosphatase activity of Echinococcus ...