Enantioselective Preparation of 2', 3'-Dideoxynucleosides and Their Analogues from Ring-Expansion of Cyclobutanones. 2. Synthesis of 2', 3'-Dideoxyribosides and ( …
Synthetic nucleosides have occupied a central role in medicinal chemistry with the observation of their activity as anticancer and antiviral agents. 2-4 Specifically, a number of 2′, 3′-dideoxynucleosides have been shown to be effective as inhibitors of human immunodeficiency virus (HIV) responsible for the etiology of acquired immune deficiency syndrome (AIDS), and a few of these derivatives (AZT, ddI, d4T, and ddC) have been ...
