Tetrahedron Letters

Microwave-assisted synthesis of 2-aminonicotinic acids by reacting 2-chloronicotinic acid with amines

CE Quevedo, V Bavetsias, E McDonald

文献索引：Quevedo, Camilo E.; Bavetsias, Vassilios; McDonald, Edward Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2481 - 2483

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被引用次数: 6

摘要

2-(Methylamino) nicotinic acid was readily prepared in high yield by reacting 2- chloronicotinic acid with 40% aq MeNH2 under microwave irradiation either at 120° C for 2h or at 140° C for 1.5 h. Subsequently, we found that a range of 2-aminonicotinic acids could be obtained under microwave heating. The optimal reaction conditions involved the use of 3equiv of amine, water as the solvent and heating at 200° C for 2h in the presence of ...