The Journal of Organic Chemistry

Lewis acid mediated fluorinations of aromatic substrates

ST Purrington, DL Woodard

文献索引：Purrington, Suzanne T.; Woodard, Daniel L. Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 142 - 145

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被引用次数: 27

摘要

Direct fluorination of aromatic substrates, PhZ (Z= C1, CHO, CH (OCH2) 2, NOz, C02CH2CH3, OH, NHCH3, OCH,, CH3), in the presence and absence of BCl, or AlCl,, has been investigated. For PhCl and PhOH, inclusion of boron trichloride increased the percent conversion and the amount of para product. However, AlCl, caused an increase in the ortho regioselectivity in the reaction with chlorobenzene. For PhCHO, inclusion of a Lewis acid ...