Synthesis and structure-activity relationships of sweet 2-benzoylbenzoic acid derivatives

A Arnoldi, A Bassoli, G Borgonovo…

文献索引：Arnoldi, Anna; Bassoli, Angela; Borgonovo, Gigliola; Merlini, Lucio; Morini, Gabriella Journal of Agricultural and Food Chemistry, 1997 , vol. 45, # 6 p. 2047 - 2054

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被引用次数: 18

摘要

Twenty-four analogues of the sweet compound 2-(4-methoxybenzoyl) benzoic acid 1 were synthesized and tasted. The structure-sweet taste relationships were studied by means of principal component analysis and by comparison with the existing sweet receptor models. Three possible glucophores were identified, which could correspond to the sites B, E1, and E2 of the Tinti-Nofre model. Some similarities between this class of compounds and ...