The Journal of organic chemistry

Nickel-catalyzed cyclization of 2-iodoanilines with aroylalkynes: An efficient route for quinoline derivatives

RP Korivi, CH Cheng

文献索引：Korivi, Rajendra Prasad; Cheng, Chien-Hong Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7079 - 7082

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被引用次数: 100

摘要

An efficient and convenient nickel-catalyzed cyclization of 2-iodoanilines with alkynyl aryl ketones to give 2, 4-disubstituted quinolines was developed. The reaction can be employed for the synthesis of naturally occurring quinoline derivatives in good yields. On the basis of the regiochemistry of the products, the possible pathway for the reaction is via the formation of o-aminochalcone.