Aqueous one-pot synthesis of pyrazoles, pyrimidines and isoxazoles promoted by microwave irradiation

V Molteni, MM Hamilton, L Mao, CM Crane…

文献索引：Molteni, Valentina; Hamilton, Matthew M.; Mao, Long; Crane, Christine M.; Termin, Andreas P.; Wilson, Dean M. Synthesis, 2002 , # 12 p. 1669 - 1674

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被引用次数: 71

摘要

Abstract Microwave irradiation promotes the conversion of enaminoketones formed in situ into a variety of heterocycles by reaction with the appropriate bidentate nucleophile. The advantages of the method over previous approaches are short reaction times and facile purification by precipitation of the products in aqueous media. Moreover the convenient one- pot procedure makes these syntheses particularly suitable for library production. Organic ...