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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and characterization of masked aminopyrazolecarboxylic acid synthons

…, BF Cain, WA Denny, JS Buckleton…

文献索引：Lee, Ho H.; Cain, Bruce F.; Denny, William A.; Buckleton, John S.; Clark, George R. Journal of Organic Chemistry, 1989 , vol. 54, # 2 p. 428 - 431

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被引用次数: 57

摘要

The synthesis of the masked aminopyrazolecarboxylic acid synthons (1 la, b and 12a, b) from pyrazole-3, 5-dicarboxylic acid (6) and the determination of their structures by X-ray crystallography are detailed. The compounds are useful for the synthesis of polypyrazolecarboxamides analogous to the DNA minor groove binding antibiotics distamycin A and netropsin.

3,5-二甲基吡唑结构式

3,5-二甲基吡唑

~%

1H-Pyrazole-5-carboxylic acid, 3-(chlorocarbonyl)-1-methyl-, methyl ester (9CI)结构式

1H-Pyrazole-5-c...

3,5-吡唑二甲酸结构式

3,5-吡唑二甲酸

~%

1H-Pyrazole-5-carboxylic acid, 3-(chlorocarbonyl)-1-methyl-, methyl ester (9CI)结构式

1H-Pyrazole-5-c...

1H-Pyrazole-3,5-dicarbonyldichloride(9CI)结构式

1H-Pyrazole-3,5...

~%

1H-Pyrazole-5-carboxylic acid, 3-(chlorocarbonyl)-1-methyl-, methyl ester (9CI)结构式

1H-Pyrazole-5-c...

1,3,5-吡唑-3,5-二羧酸三甲酯结构式

1,3,5-吡唑-3,5-二羧酸三甲酯

~%

1H-Pyrazole-5-carboxylic acid, 3-(chlorocarbonyl)-1-methyl-, methyl ester (9CI)结构式

1H-Pyrazole-5-c...

methyl 2-methyl-5-(phenylmethoxycarbonylamino)pyrazole-3-carboxylate结构式

methyl 2-methyl...

~%

3-氨基-1-甲基-1H-吡唑-5-羧酸结构式

3-氨基-1-甲基-1H-吡唑-5-羧酸

1-methyl-3-benzyloxy-carbonylamino-pyrazole-5-carboxylic acid结构式

1-methyl-3-benz...

~%

3-氨基-1-甲基-1H-吡唑-5-羧酸结构式

3-氨基-1-甲基-1H-吡唑-5-羧酸

1,3,5-吡唑-3,5-二羧酸三甲酯结构式

1,3,5-吡唑-3,5-二羧酸三甲酯

~68%

5-甲氧甲酰基-1-甲基-3-羧酸吡唑结构式

5-甲氧甲酰基-1-甲基-3-羧酸吡唑

1,3,5-吡唑-3,5-二羧酸三甲酯结构式

1,3,5-吡唑-3,5-二羧酸三甲酯

~%

methyl 2-methyl-5-(phenylmethoxycarbonylamino)pyrazole-3-carboxylate结构式

methyl 2-methyl...

5-甲氧甲酰基-1-甲基-3-羧酸吡唑结构式

5-甲氧甲酰基-1-甲基-3-羧酸吡唑

~%

methyl 2-methyl-5-(phenylmethoxycarbonylamino)pyrazole-3-carboxylate结构式

methyl 2-methyl...

1H-Pyrazole-5-carboxylic acid, 3-(chlorocarbonyl)-1-methyl-, methyl ester (9CI)结构式

1H-Pyrazole-5-c...

~%

methyl 2-methyl-5-(phenylmethoxycarbonylamino)pyrazole-3-carboxylate结构式

methyl 2-methyl...

methyl 3-(azidocarbonyl)-1-methyl-1H-pyrazole-5-carboxylate结构式

methyl 3-(azido...

苯甲醇结构式

~%

methyl 2-methyl-5-(phenylmethoxycarbonylamino)pyrazole-3-carboxylate结构式

methyl 2-methyl...

3,5-二甲基吡唑结构式

3,5-二甲基吡唑

~%

1H-Pyrazole-3,5-dicarbonyldichloride(9CI)结构式

1H-Pyrazole-3,5...

1,3,5-吡唑-3,5-二羧酸三甲酯结构式

1,3,5-吡唑-3,5-二羧酸三甲酯

~87%

1-甲基-1H-吡唑-3,5-二羧酸结构式

1-甲基-1H-吡唑-3,5-二羧酸

3-(甲氧基羰基)-1-甲基-1H-吡唑-5-羧酸结构式

3-(甲氧基羰基)-1-甲基-...

3,5-二甲基吡唑结构式

3,5-二甲基吡唑

~%

3-(甲氧基羰基)-1-甲基-1H-吡唑-5-羧酸结构式

3-(甲氧基羰基)-1-甲基-...

3,5-吡唑二甲酸结构式

3,5-吡唑二甲酸

~%

3-(甲氧基羰基)-1-甲基-1H-吡唑-5-羧酸结构式

3-(甲氧基羰基)-1-甲基-...

1H-Pyrazole-3,5-dicarbonyldichloride(9CI)结构式

1H-Pyrazole-3,5...

~%

3-(甲氧基羰基)-1-甲基-1H-吡唑-5-羧酸结构式

3-(甲氧基羰基)-1-甲基-...

5-((benzyloxycarbonyl)amino)-1-methylpyrazole-3-carboxylic acid结构式

5-((benzyloxyca...

~99%

5-氨基-1-甲基-1H-吡唑-3-羧酸结构式

5-氨基-1-甲基-1H-吡唑-3-羧酸

methyl 5-[(benzyloxycarbonyl)amino]-1-methylpyrazole-3-carboxylate结构式

methyl 5-[(benz...

~%

5-氨基-1-甲基-1H-吡唑-3-羧酸结构式

5-氨基-1-甲基-1H-吡唑-3-羧酸