Intramolecular [2+ 2] cycloadditions of ketenes to carbonyl groups. A novel synthesis of substituted benzofurans

WT Brady, YSF Giang, AP Marchand…

文献索引：Brady, William T.; Giang, Yun-seng F.; Marchand, Alan P.; Wu, An-hsiang Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3457 - 3461

全文：HTML全文

被引用次数: 39

摘要

Method B. Compound 3a (500 mg, 1.44 mmol) and sodium chloride (300 mg, excess) were suspended in dimethyl sulfoxide (DMSO, 30 mL). The reaction mixture was heated at 150" C for 1.5 h; slight darkening of the reaction mixture occurred, and a gas was evolved slowly during this period. The reaction mixture was then cooled to room temperature and water (150 mL) was added. The resulting mixture was extracted with methylene chloride (3 X 25 ...