Regioselective Alkylation of 2-Alkyl-5, 6, 7, 8-tetrahydro-3H-cycloheptimidazol-4-ones and 2-Alkyl-3H-cycloheptimidazol-4-ones

M Sonegawa, M Yokota, H Tomiyama…

文献索引：Sonegawa, Motoharu; Yokota, Masayuki; Tomiyama, Hiroshi; Tomiyama, Tsuyoshi Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 5 p. 706 - 710

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被引用次数: 13

摘要

Regioselective alkylation of 2-alkyl-5, 6, 7, 8-tetrahydro-3H-cycloheptimidazol-4-one (1) and 2-alkyl-3H-cycloheptimidazol-4-one (2) was investigated. 3-[2′-(1-tert-Butyl-1H-tetrazol-5- yl) biphenyl-4-ylmethyl]-2-propyl-5, 6, 7, 8-tetrahydro-1H-cycloheptimidazol-4-one (6) was preferentially obtained under the conditions by using NaH in DMF or THF. On the other hand, 3-[2′-(1-tert-butyl-1H-tetrazol-5-yl) biphenyl-4-ylmethyl]-2-propyl-5, 6, 7, 8- ...