Synthesis, Evaluation and Molecular Docking of Prolyl??Fluoropyrrolidine Derivatives as Dipeptidyl Peptidase IV Inhibitors

…, M Gupta, D Singh, M Kumar, P Kaur

文献索引：Sharma, Mani; Gupta, Monica; Singh, Divya; Kumar, Manoj; Kaur, Punit Chemical Biology and Drug Design, 2013 , vol. 82, # 2 p. 156 - 166

全文：HTML全文

被引用次数: 4

摘要

A series of prolyl-fluoropyrrolidine derivatives were designed, synthesized and screened for in vitro inhibition of dipeptidyl peptidase IV. The SAR study revealed the influence of substituted chemical modifications on dipeptidyl peptidase IV inhibitory activity. Among all the compounds screened, compound 9 (IC50= 0.83 lM) and 10 (IC50= 0.43 lM) possessing aryl substituted piperazine with acetamide linker resulted as most potent dipeptidyl ...