Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase

…, CD Andersson, P Wittung??Stafshede…

文献索引：Berg, Lotta; Niemiec, Moritz S.; Qian, Weixing; Andersson, C. David; Wittung-Stafshede, Pernilla; Ekstroem, Fredrik; Linusson, Anna Angewandte Chemie - International Edition, 2012 , vol. 51, # 51 p. 12716 - 12720 Angew. Chem., 2012 , vol. 124, # 51 p. 12888 - 12892,5

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被引用次数: 12

摘要

Figure 2. Dose–response curves used for determining IC50 values of (R)-6 and (S)-6 for wild- type hAChE and mAChE (with the mAChE concentration adjusted to a lower maximum activity than the hAChE concentration, for clarity). The enzymatic activity is measured as the increase in absorbance (ΔA) at 412 nm over time as a result of the enzymatic hydrolysis of acetylthiocholine.[3] Means ÆS. D. from triplicate dose response curves (goodness of fit, ...