Abstract Here, we represent preparative methods of synthesis of isomeric 3- isoxadiazolylcoumarins and their derivatives. Two new synthetic methods have been developed for 3-[1, 2, 4-oxadiazol-5-yl] coumarins I. The first method is based on a three- component condensation of coumarin-; 3-carboxylic acids, 1, 1′-carbonyldiimidazole, and amidoximes. The second method essentially uses the interaction of 5-cyanomethyl-1, 2, 4- ...