Chemistry–A European Journal

Highly Modular Synthesis of C1??Symmetric Aminosulfoximines and Their Use as Ligands in Copper??Catalyzed Asymmetric Mukaiyama??Aldol Reactions

M Langner, P Rémy, C Bolm

文献索引：Langner, Martin; Remy, Pauline; Bolm, Carsten Chemistry - A European Journal, 2005 , vol. 11, # 21 p. 6254 - 6265

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被引用次数: 60

摘要

Abstract The development of C 1-symmetric aminosulfoximines, their highly modular synthesis, and their application in enantioselective copper-catalyzed Mukaiyama-type aldol reactions between pyruvates and enolsilanes is described. In this context, the influence of the ligand architecture as well as the optimization of the reaction conditions are discussed. In detail, the dependence of the catalyst efficiency on the solvent, the metal source and the ...