Helvetica Chimica Acta

Efficient Synthesis of 14C??Labeled 1H??Pyrazolo [3, 4??d] pyrimidine and Related [4.3. 0]??Bicyclic Pyrimidino Systems

JZ Ho, KR Van Arsdale, MP Braun

文献索引：Ho, Jonathan Z.; Van Arsdale, Kyle R.; Braun, Matthew P. Helvetica Chimica Acta, 2008 , vol. 91, # 5 p. 958 - 963

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被引用次数: 4

摘要

Abstract In support of a research program aimed at discovering purine-related anticancer drug candidates, a method for the 14 C-labeling of pyrazolopyrimidines utilizing the readily available labeled starting material, sodium [14 C] formate, has been developed with a good overall yield. This new method was proven to be general in the preparation of other related [4.3. 0] heterocycles containing N, O, and S atoms. A concise synthesis of a model ...