Several 1-substituted phenyl-(4-phenylpiperidin-4-yl) methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4- benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog.
![[1-(benzenesulfonyl)piperidin-4-yl]-phenylmethanone结构式](https://image.chemsrc.com/caspic/247/922504-25-4.png)
![[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-phenylmethanone结构式](https://image.chemsrc.com/caspic/209/922504-26-5.png)
