Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine protein kinase that was first identified in the late 1970s as a consequence of its phosphorylation activity toward glycogen synthase (GS), the rate limiting enzyme of glycogen biosynthesis 1, 2. Today, it is known that GSK-3 plays an important role in various cellular and physiological events, such as the Wnt signaling pathway 3, insulin signal transduction 4, cell survival, response to DNA damage 5, ...
