Synthesis of alkylated aminofluorenes by palladium-catalyzed substitution at halofluorenes

…, Z Pingzhu, NP Ernsting, J Liebscher

文献索引：Saroja, Ginagunta; Pingzhu, Zhang; Ernsting, Nikolaus P.; Liebscher, Juergen Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 987 - 990

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被引用次数: 52

摘要

New N-substituted 2-amino-9, 9-dialkylfluorenes optionally bearing electron-withdrawing substituents such as nitro or cyano in position 7 can be synthesized starting from 2-halo-9, 9- dialkylfluorenes by Pd-catalyzed substitution with amines. Chiral amino groups can be introduced by this method too. 2-N, N-Dimethylamino-7-nitro-9 H-fluorene was obtained in a convenient way by reductive amination. The N-substituted 2-amino-7-nitro-9H-fluorenes ...