Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors

…, M Haramura, JF Cheng, T Arrhenius…

文献索引：Wallace, David M.; Haramura, Masayuki; Cheng, Jie-Fei; Arrhenius, Thomas; Nadzan, Alex M. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 1127 - 1130

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被引用次数: 10

摘要

A series of trifluoroacetophenone derivatives were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some of the 'reverse amide'analogs were found to be potent inhibitors of MCD enzyme activity. The trifluoroacetyl group may interact with the MCD active site as the hydrate in a similar fashion to the hexafluoroisopropanol analogs reported previously. Adding electron-withdrawing groups to the phenyl ring stabilizes the hydrated ...