Structure–activity relationships of pyrrole amidine antiviral antibiotics III: Preparation of distamycin and congocidine derivatives based on 2, 5??disubstituted pyrroles

…, B Yagen, R Mechoulam, Y Becker

文献索引：Bialer; Yagen; Mechoulam; Becker Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 11 p. 1334 - 1338

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被引用次数: 13

摘要

Abstract Isomers of distamycin A and tripyrrole congocidine containing 2, 5-disubstituted pyrroles were synthesized along with distamycin and congocidine homologs containing a single pyrrole ring. Selected compounds were evaluated for their cytotoxicity and antiviral activity. All of the tripyrrole derivatives tested in this series were nontoxic but were less active than distamycin A. The monopyrrole derivative, N-methyl-5-nitropyrrole-2-carboxamido-β- ...