Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo [2, 1-b][1, 3, 4]-thiadiazole derivatives

…, N Singh, AK Gadad, SS Cameotra, A Badiger

文献索引：Noolvi, Malleshappa N.; Patel, Harun M.; Singh, Navjot; Gadad, Andanappa K.; Cameotra, Swaranjit Singh; Badiger, Arvind European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4411 - 4418

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被引用次数: 63

摘要

A series of 2, 5, 6-trisubstituted imidazo [2, 1-b][1, 3, 4]-thiadiazole derivatives 4 (a–k) have been prepared by reaction of 2-amino-5-cyclopropyl-1, 3, 4-thiadiazole and an appropriate phenacyl bromide. Further 5-bromo 5 (a–k) and 5-thiocyanato 6 (a–k) derivatives were synthesized in order to study the effect of these substituents on antitumor activity. Structures of these compounds were established by IR, 1H NMR, 13C NMR and Mass spectroscopy. ...