Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor

…, J Tirado-Rives, L Leng, R Bucala, WL Jorgensen

文献索引：Dahlgren, Markus K.; Garcia, Alvaro Baeza; Hare, Alissa A.; Tirado-Rives, Julian; Leng, Lin; Bucala, Richard; Jorgensen, William L. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10148 - 10159

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被引用次数: 18

摘要

ABSTRACT: The Plasmodium falciparum orthologue of the human cytokine, macrophage migratory inhibitory factor (PfMIF), is produced by the parasite during malaria infection and modulates the host's immune response. As for other MIF orthologues, PfMIF has tautomerase activity, whose inhibition may influence the cytokine activity. To identify small- molecule inhibitors of the tautomerase activity of PfMIF, virtual screening has been ...