The proposed phenyl-A region of sigma (σ) receptors accommodates several structural features. In this study we explored the possibility that appropriate structural features located at the phenyl-A region of σ receptor sites could lead to more potent and selective agents for the sigma receptor subtypes. By keeping the phenyl-B substituent as the optimum ω- phenylpentyl moiety, and varying substituents in the phenyl-A region, we have observed ...
