Development of a Practical and Scalable Synthesis of a Potent p38 Mitogen-Activated Protein Kinase Inhibitor

…, T Kimura, T Takahashi, T Mukuta

文献索引：Yoshida, Shinya; Obitsu, Kazuyoshi; Hayashi, Yasumasa; Shibazaki, Mitsuyoshi; Kimura, Takenori; Takahashi, Takumi; Asano, Toru; Kubota, Hirokazu; Mukuta, Takashi Organic Process Research and Development, 2012 , vol. 16, # 9 p. 1527 - 1537

全文：HTML全文

被引用次数: 3

摘要

Process research and development of a practical and scalable synthetic method toward a potent inhibitor of p38 mitogen-activated protein kinase 1 is described. The medicinal chemistry synthetic method had several issues in scale-up synthesis. In contrast, the synthetic method described here does not require purification by column chromatography for all steps, and the formation of impurities is suppressed well. Aminopyrazole ring formation ...