De novo synthesis of 1, 4-dihydropyridines and pyridines

…, MM Rammah, MB Rammah, F Couty…

文献索引：Gati, Wafa; Rammah, Mohamed M.; Rammah, Mohamed B.; Couty, Francois; Evano, Gwilherm Journal of the American Chemical Society, 2012 , vol. 134, # 22 p. 9078 - 9081

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被引用次数: 66

摘要

An efficient and general method for the synthesis of 1, 4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available N-allyl- ynamides.