Tetrahedron letters

A short and efficient synthesis of N-aryl-and N-heteroaryl-N′-(arylalkyl) piperazines

…, K Kumar, A Zapf, A Tillack, M Arlt, T Heinrich…

文献索引：Michalik, Dirk; Kumar, Kamal; Zapf, Alexander; Tillack, Annegret; Arlt, Michael; Heinrich, Timo; Beller, Matthias Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2057 - 2061

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被引用次数: 34

摘要

A new synthesis of N-aryl-and N-heteroaryl-N′-(arylalkyl) piperazines using palladium- catalyzed amination of aryl bromides and heteroaryl chlorides with mono N-benzyl-or N- (arylethyl) piperazines is reported. Most coupling processes proceed in high yield and good selectivity using either diadamantyl-n-butylphosphine (), 2-(dicyclohexylphosphino)-2′-(N, N-dimethylamino) biphenyl (), or 2-(di-tert-butylphosphino) biphenyl () as ligand. Applying ...