Facile Way to Synthesize Nα??Boc??Nβ??Cbz??2, 3??Diaminopropionic Acid Derivatives via 5??Oxazolidinone

H Teng, Z Jiang, L Wu, J Su, X Feng, G Qiu…

文献索引：Teng, Hanbing; Jiang, Zhengguo; Wu, Lamei; Su, Jiangtao; Feng, Xichun; Qiu, Guofu; Liang, Shucai; Hu, Xianming Synthetic Communications, 2006 , vol. 36, # 24 p. 3803 - 3807

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被引用次数: 5

摘要

Abstract An economical and facile synthesis of Nα??Boc??Nβ??Cbz??2, 3??diaminopropionic acid derivatives is reported. The key aspect of this method is employment of N??Boc??5?? oxazolidinone moiety to simultaneously provide proper protection of α??amido and α?? carboxyl functional groups and affords the desired isocyanate 5 successfully by a Curtius rearrangement. The obtained intermediate 6 can be readily converted to various ...