The Journal of Organic Chemistry

A mild and efficient route to Schiff base derivatives of amino acids

MJ O'Donnell, RL Polt

文献索引：O'Donnell, Martin J.; Polt, Robin L. Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2663 - 2666

全文：HTML全文

被引用次数: 367

摘要

R 2 reaction is accomplished by simply stirring equimolar amounts of the two reagents in methylene chloride overnight at room temperature. Filtration and an aqueous workup followed by recrystallization leads to excellent yields of the Schiff bases (3; see Table I). With use of this general procedure, the benzophenone Schiff bases of a variety of glycine alkyl esters (3a-3e) and that from aminoacetonitrile (3f) are easily prepared. In addition, we ...