Synthesis, biological evaluation, and molecular docking studies of novel 2-styryl-5-nitroimidazole derivatives containing 1, 4-benzodioxan moiety as FAK inhibitors …

…, W Huang, JA Makawana, SB Teraiya, DJ Tang…

文献索引：Duan, Yong-Tao; Yao, Yong-Fang; Huang, Wei; Makawana, Jigar A.; Teraiya, Shashikant B.; Thumar, Nilesh J.; Tang, Dan-Jie; Tao, Xiang-Xiang; Wang, Zhong-Chang; Jiang, Ai-Qin; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 2947 - 2954

全文：HTML全文

被引用次数: 2

摘要

Abstract A series of 2-styryl-5-nitroimidazole derivatives containing 1, 4-benzodioxan moiety (3a–3r) has been designed, synthesized and their biological activities were also evaluated as potential antiproliferation and focal adhesion kinase (FAK) inhibitors. Among all the compounds, 3p showed the most potent activity in vitro which inhibited the growth of A549 with IC 50 value of 3.11 μM and Hela with IC 50 value of 2.54 μM respectively. Compound ...