Potential Growth Antagonists. I. Hydantoins and Disubstituted Glycines1, 2

LH GOODSON, IL HONIGBERG…

文献索引：Goodson,L.H. et al. Journal of Organic Chemistry, 1960 , vol. 25, p. 1920 - 1924

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被引用次数: 55

摘要

Several 2, 2-disubstituted glycines were prepared by the hydrolysis of the intermediate hydantoin in either sulfuric acid or barium hydroxide solution. Acid hydrolysis was satisfactory for the preparation of the dialkyl glycines but led to decomposition during the hydrolysis of the aryl substituted glycines. This route to the synthesis of these amino acids is considered superior to that of the Strecker method.