Molecules

Design and synthesis of new N-(5-trifluoromethyl)-1H-1, 2, 4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes

N Boechat, L Pinheiro, OA Santos-Filho, IC Silva

文献索引：Boechat, Nubia; Pinheiro, Luiz C.S.; Santos-Filho, Osvaldo A.; Silva, Isabor C. Molecules, 2011 , vol. 16, # 9 p. 8083 - 8097

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被引用次数: 17

摘要

Abstract A rational approach was used to synthesize a new set of 15 1H-1, 2, 4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1 H-, 13 C-, 19 F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified ...