Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties

IA Murray, G Krishnegowda, BC DiNatale…

文献索引：Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966

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被引用次数: 49

摘要

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. However, the role of the AHR in normal physiology is still an area of intense investigation. For example, this receptor plays an important role in certain immune responses. We have previously determined that the AHR can mediate repression of acute-phase genes in the liver. For this observation to be ...