9-Benzylidene-naphtho [2, 3-b] thiophen-4-ones as Novel Antimicrotubule Agents Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization

…, P Schmidt, S Baasner, KJ Böhm, K Müller…

文献索引：Mueller, Klaus; Guerster, Dieter; Piwek, Susanne; Wiegrebe, Wolfgang Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4099 - 4107

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被引用次数: 23

摘要

A novel series of 9-benzylidene-naphtho [2, 3-b] thiophen-4-ones and structurally related compounds were synthesized and evaluated for their ability to inhibit tubulin polymerization. The 4-hydroxy-3, 5-dimethoxy-benzylidene analogue 15d was identified as a potent