Synthesis and biological activity of N-substituted aminocarbonyl-1, 3-dioxolanes as VLA-4 antagonists

…, S Nair, VP Palle, S Dastidar, A Ray, MS Alam…

文献索引：Rehman, Abdul; Soni, Ajay; Naik, Keshav; Nair, Sreeji; Palle, Venkata P.; Dastidar, Sunanda; Ray, Abhijit; Alam; Salman, Mohammad; Cliffe, Ian A.; Sattigeri, Viswajanani Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5514 - 5520

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被引用次数: 5

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities. ... Pyrolidine ring in the N-acylphenylalanine class of VLA-4 ...

24424-99-5

二碳酸二叔丁酯

~98%

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