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Tetrahedron

The synthetic versatility of alkoxycarbonyl-and hydroxymethyl-piperazine-2, 5-diones

CLL Chai, JA Elix, PB Huleatt

文献索引:Chai, Christina L.L.; Elix, John A.; Huleatt, Paul B. Tetrahedron, 2005 , vol. 61, # 36 p. 8722 - 8739

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被引用次数: 17

摘要

Alkoxycarbonylpiperazine-2, 5-diones are versatile precursors for the α-functionalisation of piperazine-2, 5-diones. The alkoxycarbonyl group activates the α-carbon position to alkylation reactions and this provides a mild and selective method for the extension of the carbon framework of piperazine-2, 5-diones. In addition, the alkoxycarbonyl group can be converted to the carboxy group, which in turn can be 'deleted'or manipulated for the ...